Manahatta, the "hilly island," is the land of the Lenape people. The Greene Street block was near a cluster of Lenape settlements, as well as a system of trails that stretched as far north as Massachusetts.
Map: GIS Digital Elevation Map (DEM), Welikia Project; with Lenape info from Sanderson E. W. (2009). Mannahatta: A Natural History of New York City. New York: Abrams, 107.