The first residents of the Greene Street block on record were four "half-free" slaves: Gratia D’Angola, Pieter Van Campen, Marycke, and Anthony Portuguese. They were given parcels of land by the Dutch in the 1640s, to serve as buffer against fighting with the Lenape. You can see their names, as well as the names of prominent families like Dyckman and Bayard, on this map of the overlapping Dutch land grants.
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I.N. Phelps Stokes, The iconography of Manhattan Island, 1498-1909:compiled from original sources and illustrated by photo-intaglio reproductions of important maps, plans, views, and documents in public and private collections, 1928.